Which Way Was I Going? Contextual Retrieval Supports the Disambiguation of Well Learned Overlapping Navigational Routes

Which way was I going? Contextual retrieval supports the disambiguation of well learned overlapping navigational routes.

Groundbreaking research in animals has demonstrated that the hippocampus contains neurons that distinguish between overlapping navigational trajectories. These hippocampal neurons respond selectively to the context of specific episodes despite interference from overlapping memory representations. The present study used functional magnetic resonance imaging in humans to examine the role of the h...

I-10: The Oocyte Express Way to Reprogramming Supports Double Nucleus Transplantation

Studies on cell fusion-mediated nuclear reprogramming have led to the breakthrough of the induced pluripotent stem (iPS) cell technology. While this technology has neared stem cells to applications more than any other method, the mechanistic bases of reprogramming remain largely unsolved. In this context, comparative studies of oocyte and cell fusion-mediated reprogramming hold the greatest pro...

Twelve Lessons (Most of Which I Learned the Hard Way) for Evolutionary Psychologists

A high-resolution study of hippocampal and medial temporal lobe correlates of spatial context and prospective overlapping route memory.

When navigating our world we often first plan or retrieve an ideal route to our goal, avoiding alternative paths that lead to other destinations. The medial temporal lobe (MTL) has been implicated in processing contextual information, sequence memory, and uniquely retrieving routes that overlap or "cross paths." However, the identity of subregions of the hippocampus and neighboring cortex that ...

The hippocampus and disambiguation of overlapping sequences.

Recent models of hippocampal function emphasize its potential role in disambiguating sequences of events that compose distinct episodic memories. In this study, rats were trained to distinguish two overlapping sequences of odor choices. The capacity to disambiguate the sequences was measured by the critical odor choice after the overlapping elements of the sequences. When the sequences were pre...